Slide 1
I am Elcio and am eager to speak with you and mainly teach you about the medication that is well known to all of us, whether on a professional or personal level. Ibuprofen is widely recognized for its analgesic, anti-inflammatory, and antipyretic properties.
Today I want to study the pharmacology of Ivory in addition to its brand and generic names, their dosing rules, indications, side effects, contraindications, safety in pregnancy, cost, and a patients case study. Furthermore, I will analyze studies documenting the use of ibuprofen, nurse practitioner patient education, my role in prescribing and follow-up care, and so forth. To learn more, visit NUR 600 Module 2 Assignment Begin Research for your Drug Projects.
Slide 2
For example, ibuprofen is classified as a non-steroidal anti-inflammatory agent. It has unique sides because it hits both COX-1 and COX-2. Both of them release Prostaglandins which are inflammatory, pain-inflicting, and fever-producing lipid molecules. Ibuprofen functions through decreasing the inflammation, pain, and fever by blocking the creation of these lipid molecules (Qureshi and Dua, 2022).
Slide 3
After one or two hours of taking in ibuprofen , the body should have maximum plasma concentration. This is because ibuprofen gets absorbed directly from the stomach. Roughly one percent of ibuprofen is not bound to plasma proteins, and most of it gets oxidized in the liver. It is mostly the kidneys that excrete the metabolites, together with some of the unaltered drugs. Ibuprofen is estimated to have an elimination half-life of about two to four hours, therefore multiple doses can be taken during the daytime (Qureshi and Dua, 2022).
Slide 4
Advil, Motrin, and Nurofen refer to different brands under which Ibuprofen is sold. Ibuprofen is also the name registered with the FDA, so it’s a drug like any other (Zurab Tsetskhladze et al, 2023). As mentioned before, patients and consumers may have access to many forms of branding for Ibuprofen aside from its generic form. The brand may differ, but the active component of Ibuprofen does not change.
Adapt Pharmacare has the rights to manufacture and sell Ibuprofen under its brand name and, therefore, can use it on Advil, Motrin, and Nurofen as these brands have Ibuprofen. The brand that a consumer picks might be contoured by a preference, marketing or stock offers that are favorable to them (Zurab Tsetskhladze et al, 2023). All brands of Ibuprofen, including their marketing, have an identical therapeutic claim for the drug.
Slide 5
Ibuprofen dosage relies on the disease, side impact reality, and patient’s age. The usual adult part is 200 to 800 mg each 6 to 8 hours, with a maximum daily intake of 3200 mg (Muhammed Ershad and Vearrier, 2020). Weight-based dosing for pediatric patients is 10 mg/kg each 6-8 hours, with serious adherence to maximum daily cutoff focuses to avoid harmfulness (Muhammed Ershad and Vearrier, 2020).
Slide 6
Ibuprofen treats several circumstances. It treats delicate to outrageous pain, similar to headaches, toothaches, menstrual cramps, and musculoskeletal discomfort. It also decreases arthritis, inflammation, and fever. Because of its versatility, Ibuprofen is useful in acute and constant settings (Sohail et al., 2023).
Slide 7
As with other medications, Ibuprofen can produce harmful effects. Side effects such as nausea, vomiting, dyspepsia, intoxication, and headaches are the most common. Some side effects that are deemed more severe include gastrointestinal bleeding or ulceration, chronic kidney disease, and even myocardial infarction or cerebrovascular accidents. All of these side effects pose significant risk, and are impactful when determining the positive uses of prolonged ibuprofen usage (Sohail et al., 2023).
Slide 8
It is not advised to use this medication for patients with severe kidney or liver of undetermined hippocratic and unreasonable radial tenderness to Ibu and other NSAID medications. It is recommended for people suffering from chronic CABG surgery not to use it due to the lack of good electrodes and cardiovascular problems (Trung and Bajaj, 2023).
Slide 9
The FDA classifies Ibuprofen as a Category D medication in the third trimester according to adverse reaction data from investigational or marketing experience or human research (Trung and Bajaj, 2023). This classification is essential because Ibuprofen presents exceptional dangers to the creating lacking organism in late pregnancy. Premature ductus arteriosus conclusion is a significant worry of third-trimester ibuprofen use. The ductus arteriosus is a critical fetal blood artery.
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It allows the blood to bypass the lacking lungs (Trung and Bajaj, 2023). This vessel closes immediately after conveyance when the infant breathes air and the lungs start oxygenating the blood. NSAIDs like Ibuprofen smothers prostaglandin creation, disturbing this mechanism. Prostaglandins maintain the fetal ductus arteriosus open. Premature artery conclusion can cause dangerous fetal pulmonary hypertension and heart failure (Trung and Bajaj, 2023).
Slide 10
Ibuprofen, especially the generic adaptations of the drug, confesses all. Over-the-counter generic ibuprofen costs $10-$20 for 100 to 200 mg tablets (Trung and Bajaj, 2023). Brand-name Advil and Motrin are more costly anyway equally useful and safe.
Slide 11
Jane Doe, a 45-year-more established individual with osteoarthritis who had increased knee discomfort, introduced in the trauma local area. She attempted Acetaminophen before, yet it has not assisted her with pain. After careful consideration, I proposed Ibuprofen for her pain. Given her condition and past unfortunate reaction to Acetaminophen, 400 mg of Ibuprofen each 6-8 hours as expected for pain, not to surpass 2400 mg each day, was a reasonable decision, and she was proposed it.
A twofold masked study indicated that Ibuprofen decreased pain and dealt with physical capability in osteoarthritis patients better than Acetaminophen (Lim and Al-Dadah, 2022). Another systematic audit and meta-analysis of NSAIDs for osteoarthritis saw that Ibuprofen is efficacious and particularly tolerated for momentary usage (Cadet and Maheu, 2021).
Slide 12
While educating patients about Ibuprofen, I will emphasize that they take It with meals to decrease any sort of gastrointestinal discomfort, similar to pain. I will talk about gastrointestinal challenges and indicators of major side effects, as gastrointestinal passing on (Muhammed Ershad and Vearrier, 2020). I will also encourage patients to avoid taking other NSAIDs without a specialist’s approval and to search for medical assistance for serious side effects.
Slide 13
In my role as Nurse Practitioner, I assess the pain that Jane is experiencing and consider if Ibuprofen is an appropriate medicine given her medical history and condition. I would suggest Ibuprofen, monitor the dosage, and provide instructions regarding its use, side effects, and safety. Her surveillance includes seeing and following up. A two-week follow-up visit will evaluate the extent of relief from pain and other side effects. I will also include in the prolonged surveillance blood test and physical exams of her renal and gastrointestinal systems. If Jane has side effects, or the pain control is inadequate, I will make dosage adjustments, or pursue alternative methods.
Slide 14
- Conclusion
In conclusion, Ibuprofen can treat pain and inflammation, yet dosing, side effects, and patient-unequivocal considerations should be considered to guarantee safety and efficacy. Through teaching, seeing, and follow-up, healthcare suppliers can assist patients with maximizing results and breaking point dangers.
- National Library of Medicine (NIH). Ibuprofen: Uses, Dosage, Side Effects
https://medlineplus.gov/druginfo/meds/a682159.html
FDA. Ibuprofen Drug Safety Communication
Mayo Clinic. Ibuprofen (Oral Route)
https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/description/drg-20070602
PubMed Central. Ibuprofen: Pharmacology, Therapeutics, and Side Effects
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193657/
Drugs.com. Ibuprofen Information
https://www.drugs.com/ibuprofen.html